Rob Lowe Gets Mistaken
In a hilariously star-studded mix-up, actor Rob Lowe found himself the unexpected subject of celebrity confusion this week when a Hollywood tour bus rolled by and the guide excitedly pointed him out — as John Stamos.
The moment occurred on Sunset Boulevard on Tuesday afternoon, where Lowe was casually walking with a coffee in hand, dressed in classic California-cool: fitted jeans, a crisp button-down, and aviator sunglasses. A passing open-roof tour bus full of starry-eyed tourists slowed down, its microphone-crackling guide standing up and gesturing toward Lowe.
“There he is, folks — John Stamos! Uncle Jesse himself!” the guide reportedly shouted, prompting a flurry of camera clicks and enthusiastic waves from passengers.
Lowe, known for his roles in The West Wing, Parks and Recreation, and most recently Netflix’s Unstable, reportedly paused mid-step, turned to face the bus, and smiled — not in acknowledgment, but in amused disbelief. According to eyewitnesses, he raised an eyebrow, chuckled, and mouthed, “Not Stamos.”
A Case of Classic Hollywood Mistaken Identity
The incident immediately gained traction online after one of the passengers posted a TikTok of the mix-up, captioning the video: “POV: Your tour guide swears Rob Lowe is John Stamos and he hears it.” The clip racked up over 3 million views in under 24 hours.
In the video, Lowe appears unbothered, even amused, by the case of mistaken identity. His signature grin and casual wave to the bus only fueled the confusion for some commenters, who debated whether it really was Lowe or Stamos in the clip.
“They could be cousins at this point,” one user commented. “Same ageless genes. Same hair. Totally understandable.”
Others pointed out that while the two actors do share some physical similarities — notably, full heads of lustrous hair, eternally youthful complexions, and decades-long tenures as heartthrobs — they’ve cultivated distinct personas in Hollywood.
Lowe is best known for his mix of sharp political drama and dry comedy, while Stamos has long been associated with his charismatic sitcom roles, including the beloved “Uncle Jesse” from Full House.
Lowe’s Response: “Not My First Rodeo”
The story took another delightful turn when Rob Lowe himself addressed the incident on Instagram. Posting a freeze-frame from the viral video, he captioned the image:
“When your tour guide thinks you’re John Stamos… I’ll take it. @johnstamos, coffee soon?”
Within minutes, John Stamos chimed in with a repost on his own story, adding a laughing emoji and writing, “You wish, bro. But thanks for keeping the myth alive.”
Fans of both actors delighted in the bromantic banter, with many demanding a joint project. One fan tweeted: “We need a buddy comedy. Rob Lowe and John Stamos. Title it: Mistaken Identity. You’re welcome, Hollywood.”
Not the First, Probably Not the Last
Mistaken celebrity identity is practically a rite of passage in Hollywood, and Lowe has spoken candidly in the past about being confused with other famous faces. In interviews, he’s said he’s been mistaken for everyone from Matthew McConaughey to Rob Riggle — and now, officially, John Stamos.
“I’ve been in this business long enough to know you’re always someone else to somebody,” Lowe once said on The Graham Norton Show. “And honestly, if I’m being mistaken for people like Stamos, I’m doing alright.”
The incident also sparked a wider conversation online about the enduring allure of the “ageless celebrity.” Both Lowe and Stamos are in their early 60s but continue to captivate audiences with their charisma, good looks, and social media savvy.
As one fan put it on Instagram: “Rob Lowe being mistaken for John Stamos is the most 2025 thing ever. Legends, both of them.”
Final Thoughts: A Hollywood Moment
In a town where perception often blurs reality, Rob Lowe’s mistaken identity on a Hollywood tour bus is a charming reminder that even stars can be fans — and foils — of each other. Whether you’re Team Lowe or Team Stamos, there’s no denying both actors have aged like fine wine and carry enough charm to confuse a dozen double-decker buses.
As for the tourists on that bus? They may not have seen Uncle Jesse that day — but they definitely got a true Hollywood moment.
